Effect of cyclophosphamide administration during late gestation period on post natal survival and growth of rats

Dr. K.C. Singh; Dr. Gunjan Rai; Mr. Rahul Rai

Volume : VI, Issue : VI, June - 2017

Effect of cyclophosphamide administration during late gestation period on post natal survival and growth of rats

Dr. K. C. Singh, Dr. Gunjan Rai, Mr. Rahul Rai

Abstract :

The aim of this study was to compare the teratogenic effects cyclophosphamide among the pregnant female rats exposed with cyclophosphamide (CP) with the normal pregnant. 29 pregnant female rats were involved. 6 were control (injected normal saline) and rest were categorized as group 1(7 rats), group 2(7 rats) and group 3(9 rats), which received CP(10mg/kg body weight) in increasing order of single dose, double dose and triple dose respectively. The fetus or the newborns were analysed for litter size, mortality rate, weight, CR length, tail length and PC length. Litter size in control group was 100% while it decreased in dose dependent manner in the rats exposed to CPA. The gestation period was also prolonged in these drug treated rats. We also found significant decrease in body weight, tail length, CR length and PC length in the offspring of the female rats treated with CP.