Effect of Drotaverine on cervical dilatation â€“ A comparative study with Valethamate bromide.

Dr.Vijaya Lakshmi K; Dr. Pavani Jannu; Dr.B.Naveena

Volume : V, Issue : XII, December - 2016

Effect of Drotaverine on cervical dilatation â€“ A comparative study with Valethamate bromide.

Dr. Vijaya Lakshmi K, Dr. Pavani Jannu, Dr. B. Naveena

Abstract :

ObjectivesTo compare the efficacy and safety of Drotaverine hydrochloride and Valethamate omide in shortening of 1st stage of labour. Study design ?e prospective study was conducted at ALLURI SITARAMA RAJU ACADEMY OF MEDICAL SCIENCES, ELURU between August 2013 to October 2015. 300 patients in labor ( spontaneous or induced ) were selected. ?ey were equally divided into three groups. In group 1, an injection of Valethamate omide 8 mg intramuscularly every half an hour for three doses. Group 2 consisted of 100 women who were administered one injection of Drotaverine hydrochloride 40 mg intramuscularly and repeated 2 hourly for maximum of three injections. Group 3 (n=100) acted as Control and were not given any drug. Comparative analysis was carried out regards to duration of early active phase of labour, rate of cervical dilatation, injection to delivery interval, mode of delivery, maternal outcome. t – test and chi – square test was used as statistical test of significance. Result 1. ?e average injection to delivery interval in Drotaverine is 192.26�75.155 minutes and in Valethamate is 262.72�134.5 minutes. ?e injection to end of first stage is 168.89�69.57 minutes in Drotaverine and 241.46�130.27 minutes in Valethamate. 2 ?e rate of cervical dilatation in Primigravida was 1.974 �1.95 cm/hr in Valethamate , 2.188�0.63 cm/hr in Drotaverine and 1.163�0.45 cm/hr in Control group. In Multigravidae the values were 1.739�0.96 cm/hr in Valethamate, 2.496�1.23 cm/hr in Drotaverine and 1.482�0.58 cm/hr in Control group. Conclusion : In conclusion, as per the present study, it is found that the Drotaverine is superior to Valethamate as it reduces the duration of labor more effectively with very less adverse effects on mother and fetus compared to Valethamate and contol groups. When compared to Valethamate, Drotaverine is cost effective. Hence, Drotaverine can be recommended for shortening the duration of labor by hastening the cervical dilatation.