EFFECT OF GABAPENTIN ON ATTENUATION OF HEMODYNAMIC REPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION UNDER BIS CONTROLLED ANAESTHESIA: A PLACEBO CONTROLLED PROSPECTIVE RANDOMIZED CONTROLLED STUDY

Meeta Yadav; Meenal Jindal; Ghanshyam Singh Rathore; R.K.Aseri

Volume : IX, Issue : IV, April - 2020

EFFECT OF GABAPENTIN ON ATTENUATION OF HEMODYNAMIC REPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION UNDER BIS CONTROLLED ANAESTHESIA: A PLACEBO CONTROLLED PROSPECTIVE RANDOMIZED CONTROLLED STUDY

Meeta Yadav, Meenal Jindal, Ghanshyam Singh Rathore, R. K. Aseri

Abstract :

Background and Aims: Laryngoscopy and intubation cause sympathetic stimulation and arousal reactions. We evaluated the role of gabapentin on hemodynamic responses to laryngoscopy and intubation as compared to placebo, when depth of anaesthesia was maintained at a constant bispectral index (BIS) range 40‑50 (�5). Methods: Sixty patients were randomised to receive either gabapentin (Group G), or multivitamin tablet (Group P) orally 120 min before induction of anaesthesia in a double blind manner. After achieving BIS 40–50 (�5), laryngoscopy and intubation were performed. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded pre‑drug, after premedication, after induction, and at 1,3,5 and 10 min following intubation. Statistical analysis was done using Chi‑square test and t–test. Results: HR remained elevated than baseline till 10 min after intubation in both groups. Blood pressure rise was seen only at one minute after intubation which was insignificant in gabapentin group and then became lower than baseline in both groups till 10 min after intubation. Difference in BP in both groups was statistically significant (p<0.05) till 5 min after intubation and not significant at 10 min (p>0.05). Conclusion: Gabapentin is safe and effective method for attenuation of blood pressure in response to direct laryngoscopy and endotracheal intubation. Gabapentin does not attenuate heart rate