Effect of glycemic control on serum C  reactive protein and development of nephropathy in type 2 diabetes mellitus.

Ankur Mathur; Satish Kumar Vardey; Dharamveer Yadav; Bhawani Kochar

Volume : VI, Issue : IV, April - 2017

Effect of glycemic control on serum C reactive protein and development of nephropathy in type 2 diabetes mellitus.

Ankur Mathur, Satish Kumar Vardey, Dharamveer Yadav, Bhawani Kochar

Abstract :

Aim: To assess the association between serum CRP concentration and the risk of development of diabetic nephropathy with glycemic control.

Material and Methods: A hospital based observational study was conducted on ninety clinically established non–insulin dependent diabetes mellitus (NIDDM) subjects having relevant clinical and laboratory measurements. subjects were divded into two groups on the basis of urinary albumin excretion. Urinary albumin excretion was measured by qualitative Dipstick method. CRP and HbA_1C were measured using Immunoturbidimetric assay & Latex agglutination inhibition assay respectively.

Results: The mean HbA_1C level and serum CRP levels in diabetic subjects with microalbuminuria were higher and statistically significant (P ≤ 0.001). The serum CRP levels and HbA_1C levels in NIDDM subjects were statistically significant and positively correlated (P < 0.001 and r = 0.92).

Conclusion: In this study, the serum CRP concentrations increased with increasing HbA_1C levels.which, suggests an association between glycemic control and systemic inﬂammation in people with established diabetes.