Volume : VII, Issue : XI, November - 2018

EFFECT OF INTRAVENOUS ONDANSETRON ON HAEMODYNAMIC PARAMETERS IN TOTAL ABDOMINAL HYSTERECTOMY POST SUBARACHNOID BLOCK" A DOUBLE BLIND RANDOMIZED CONTROL STUDY

Dr. Hina Khan, Dr. Ritu Pauranik

Abstract :

 BACKGROUND:

Subarachnoid block (SAB) is the preferred method of anaesthesia for lower abdominal surgeries, but is associated with hypotension and adycardia, which may be deleterious to the patients. Studies suggest that in the presence of decreased blood volume, serotonin (5–HT) may be an important factor inducing the Bezold Jarisch reflex (BJR) via 5–hydroxytryptamine 3 (5–HT3) receptors located in intracardiac vagal nerve endings. In this study, we evaluated the effect of ondansetron, as a 5–HT3 receptor antagonist, on the haemodynamic response post SAB in patients undergoing elective total abdominal hysterectomy (TAH).

METHODS:

One hundred patients scheduled for elective TAH were allocated into two groups using computer generated randomization chart. 5 minutes prior to induction of SAB, Group O (n = 50) received intravenous ondansetron 4 mg; Group N (n = 50) received normal saline. Blood pressure, heart rate and vasopressor requirements were assessed.

RESULTS:

There was fall in systolic, diastolic and mean arterial pressure as well as in heart rate, compared with baseline values in both the groups. Except for the baseline, at all other time intervals, statistically significant difference in blood pressure was seen between the ondansetron and normal saline group, with a lower systolic diastolic and mean arterial pressure in normal saline group as compared to ondansetron group (P = <0.0001). No significant difference in heart rate values were observed between the groups (P = >0.05).

Reduction in use of vasopressor, incidence of nausea and vomiting and occurrence of shivering were also significant between the groups.

CONCLUSION:

Thus, we conclude in our study that prophylactic i/v use of 4 mg ondansetron reduces the severity of SAB induced hypotension, the need for rescue vasopressor, incidence of nausea and vomiting and occurrence of shivering.

SUMMARY:

 

From the present study it can be summarized that Intravenous Ondansetron 4mg when given 5 minutes prior to subarachnoid block for total abdominal hysterectomy is effective in preventing hypotension with minimal side effects and reduced requirement of rescue vasopressor.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

EFFECT OF INTRAVENOUS ONDANSETRON ON HAEMODYNAMIC PARAMETERS IN TOTAL ABDOMINAL HYSTERECTOMY POST SUBARACHNOID BLOCK , Dr. Hina Khan, Dr. Ritu Pauranik , INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7|Issue-11| November-2018

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