IJSR - International Journal of Scientific Research

Dr. Vikrant Gupta; Dr. Sonika Gupta; Dr. Shivani Gupta

Volume : VIII, Issue : VIII, August - 2019

Effect of mifepristone in the treatment of uterine myoma in perimenopausal women

Dr. Vikrant Gupta, Dr. Sonika Gupta, Dr. Shivani Gupta

Abstract :

Objectives: – To evaluate the effect of mifepristone (25mg) on symptomatic myoma in perimenopausal women. Material and Methods: – 50 perimenopausal women of age 35–50years having symptomatic myoma were selected form Gynecology OPD and given 25mg Mifepristone once daily continuously for three months. Variables as baseline uterine size, uterine volume, myoma size, volume, their number, position, characteristics, hemoglobin and blood parameters were taken and followed monthly for six months. Bleeding and pain scores were checked on monthly visits. Changes in above parameters were tabulated during the first three months treatment phase and then next three months post treatment phase for analysis. Statistical Analysis: – Was done by calculating mean, standard deviation, standard error and percentage distribution of variables. Results: – Menorrhagia was the most common symptom which led patients to report to hospital. Mean uterine volume reduced to 63.69% of base line, Mean dominant Myoma volume reduced to 53.61% of base line and hemoglobin raised to 137% after complete three months of treatment. Changes persisted in next three months post–treatment follow–up, while hysterectomy was required in one case. Conclusion: – Three Months treatment of 25mg Mifepristone effectively controls bleeding, reduces the uterine and myoma volume and thus can avoid blood transfusion and hysterectomy in a lot of symptomatic myoma cases.