IJSR - International Journal of Scientific Research

Volume : VII, Issue : IV, April - 2018

Dr. Trishala Jain, Dr. B. P. Meena

The aim of this study is to evaluate the effects of clonidine as premedication on hemodynamic response during laparoscopic cholecystectomy.

Clonidine has been shown to reduce perioperative haemodynamic instability.Sixty adult patients of ASA physical status I & II scheduled for

elective laparoscopic cholecystectomy were recruited for a propective randomized, double–blinded comparative stydy, All the patients were

anesthetized by standard technique. Induction and maintainince of anaesthesia was same in both the groups Pneumoperitoneum was done with

CO2 gas and intra abdominal pressure was Kept upto 14 mm Hg. Heart rate, systolic, diastolic and mean arterial pressure were recorded at different

time intervals.

Material and Method :– This study of oral clonidine to attenuate the hemodynamic changes to Pneumoperitoneum during laparoscopic

Cholecystectomy was conducted in the Department of Anaesthesilogy at SMS Hospital and Medical college, Jaipur. In this study sixty adult

patients, belonging to ASA Grade I or II of Either sex , Posted for elective laparoscopic cholecystectomy were Selected for this randomized double

blind study. Preoperative history taking and clinical examination was done on the day before surgery. Routine investigations were done in all

patients. Special investigations were advised in selected patients. The nature of study and procedure was explained to the patient and written

informed consent was taken.

CONCLUSION :– In conclusion, premedication with 150 ug oral clonidine, has been found to be relatively safe as well as effective method that

provides stable haemodynamics and protection against stress response triggered by pneumoperitoneum.