IJSR - International Journal of Scientific Research

Dr. CK. Anil; Dr. Vemuri Reethikaa; Dr. Pooja Yenubary

Volume : IX, Issue : VI, June - 2020

Effect of Premedication with Anti inflammatory Drugs, COX INHIBITORS and Corticosteroids on PostEndodontic Pain: A Clinical Trial

Dr. Ck. Anil, Dr. Vemuri Reethikaa, Dr. Pooja Yenubary

Abstract :

Aim: To estimate and compare the competence of preoperative single dose of nonsteroidal anti‑inflammatory drug, 1)piroxicam (20 mg),propionic acid derivate2) ibuprofen (400mg),COX2 inhibitor 3)(celecoxib 200mg), 4)corticosteroid drugs – dexamethasone (4 mg) 5)placebo for the prevention and management of post endodontic pain. Materials and Methods: A total of 150 volunteers selected for nonsurgical root canal therapy were randomly divided into the following four groups (n = 30 each) according to preoperative medication given. Group 1: piroxicam (20 mg); Group 2: ibuprofen (400 mg); Group 3: celecoxib (200 mg); Group 4: dexamethasone (4 mg) and Group 5: placebo. The preoperative medications were administrated 1 hr before the start of standard endodontic treatment. Patients were instructed to complete a pain diary using Visual Analog Scale preoperatively at 6‑, 12‑, 24‑, 48‑, and 72‑h intervals after root canal instrumentation. Statistical Analysis: The correspondence between preoperative endodontic pain to postoperative pain and pair‑wise comparison of five groups was evaluated by Kruskal–Wallis analysis of variance test followed by Mann–Whitney U‑test. Results: Compared to the placebo group, the other groups that included piroxicam, ibuprofen celecoxib , dexamethasone resulted in a statistically significant fall in post endodontic pain at 6, 12, and 24 h (P < 0.05)