Effect of Progestin (Depot Medroxy Progesterone Acetate) on Testis and Pituitary gland :Ultrastructural and Biochemical studies.

M.S.Sastry; S.S.Gupta

Volume : IV, Issue : XI, November - 2015

Effect of Progestin (Depot Medroxy Progesterone Acetate) on Testis and Pituitary gland :Ultrastructural and Biochemical studies.

M. S. Sastry, S. S. Gupta

Abstract :

The effect of Depot Medroxy Progesterone Acetate (Depo Provera– DMPA) at the dose of 1mg/animal/day for 30 on testis and pituitary gland in Indian palm squirrel Funambulus pennanti has been studied. The treatment caused significant changes in ultra structural and Biochemical parameters. The changes seen in testis were damage to Golgi, early cap and late cap phase spermatid as well as spermatogonial cells. The treatment also revealed pronounced effects on two Gonadotrophs; FSH and LH as well as Lactotrophs (PRL). The changes in anterior Pituitary include significant reduction in number and size of gonadotrophic cells, secretory granules, regression of RER and Golgi vesicles. DMPA also caused decrease in Acid and alkaline phosphatases, slight decrease in Citric acid content, significant decrease in total proteins and increase in fructose content. The ultra structural and Biochemical changes were correlated as the cellular degeneration is responsible for decrease in the activity of marker enzymes. Thus overall result suggested a strong anti–androgenic effect of DMPA.