IJSR - International Journal of Scientific Research

K. Sujatha; M. Siva Sankar; P. NEERAJA

Volume : III, Issue : I, January - 2014

EFFECT OF SODIUM SELENITE ON SELECTED ENZYMES IN LIVER AND BRAIN TISSUES OF ALBINO RAT UNDER AMMONIA STRESS

K. Sujatha, M. Siva Sankar, P. Neeraja

Abstract :

Ammonia is a major by product of protein and nucleic acid catabolism, and its nitrogen can be incorporated into urea, amino acids, nucleic acids and many other nitrogenous compounds. Selenium plays a vital role in the body being an integral component in certain enzymes, protecting cell memanes. The present study aims to examine whether selenium alleviates ammonia stress conditions. The LD₅₀ of Ammonium Sulphate and Sodium Selenite were determined. After toxicity testing evaluation are 91.5mg/kg body weight for ammonium sulphate and 1.5mg/kg body weight for sodium selenite through intraperitoneal method to rats for one week. After one week treatment, biochemical parameters like free amino acids, aspartate aminotransferase (AST) and alanine aminotransferase (AlAT) were estimated in liver and ain tissues of albino rats by using standard methods. The impact of sodium selenite in rat under ammonia stress will be discussed.