Effect of Surfactants on Morphology and Drug  Release of Ethylcellulose Microspheres

Shankrayya. M; Venkatesh J S; Sindhu Patil; Santhosh Raj M; Jagadish Rabadia

Volume : II, Issue : VII, July - 2013

Effect of Surfactants on Morphology and Drug Release of Ethylcellulose Microspheres

Shankrayya. M, Venkatesh J S, Sindhu Patil, Santhosh Raj M, Jagadish Rabadia

Abstract :

An emulsion-solvent evaporation technique was used to prepare microspheres of aceclofenac using ethyl cellulose as a carrier. The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The surfactant concentration was found to be greatly affected the microsphere size distribution and dissolution. The mean diameter of the microspheres decreased exponentially as a function of surfactant concentration. The microsphere size distribution became narrower with increasing surfactant concentration. A clear correlation between the types of surfactant on mean diameter of the microspheres was found. Results have indicated that the incorporation of hydrophilic surfactant (tween-80) gave larger microspheres, where as incorporation of the hydrophobic surfactant (span-80) gave smaller microspheres and hydrophilic surfactant containing microspheres had higher drug release rate compared to hydrophobic surfactant containing microspheres.