Effect Of Tween 20 And Tween 40 Surfactants On 5-Fluorouracil Niosomes

Volume : VII, Issue : IV, April - 2018

Vikesh Shukla, Mastiholimath Vs

Niosomes (Non–ionic surfactant vesicles) have become promising alternatives to liposomes because they are more economic and chemically

stable. Hence, Niosomes of 5–Fluorouracil were prepared by using Tween 20 and Tween 40, by ether injection method (EIM). Niosomes of Tween

40, which proved to be the best formulation, showed a mean vesicle size of 5μm and entrapment efficiency of Tween 20 and Tween 40 were found to

be 46.40% and 39.20%. The cumulative % drug release of Tween 20 and Tween 40 were 86.41% and 92.84% respectively in 12 h. The tissue

distribution studies of Tween 40 formulation reveal that the drug loaded niosomes showed preferential drug targeting to liver followed by spleen

and lungs.