Effect of Vitamin D Supplementation in  Hypertensive Patients with Vitamin D  Defiency: A Comparative Study

Dr. Rishu Bhanot; Dr. C. K. Vyas; Dr.Damandeep Singh

Volume : II, Issue : V, May - 2013

Effect of Vitamin D Supplementation in Hypertensive Patients with Vitamin D Defiency: A Comparative Study

Dr. Rishu Bhanot, Dr. C. K. Vyas, Dr. Damandeep Singh

Abstract :

Study Design: to study the effect of Vitamin D3 supplementation on Blood pressure in Hypertensive subjects. Background: Low 25–hydroxy–vitamin D (25(OH) D) levels are inversely related to blood pressure (BP) and have been associated with hypertension. We wanted to test the hypothesis that correction of Vitamin D3 deficiency by supplementation lowers BP in patients with hypertension. Methods: We investigated the effect of 1000mg calcium and 1000IU Vitamin D3 per day in a prospective, cohort study in 146 hypertensive patients visiting in OPD of NHL Municipal Medical College, Ahmedabad, India Results: A total of 108 patients (mean age 67 � 3.6years) with a baseline vitamin D3 of 15 � 3.2 ng/ml completed the study. Compared with Calcium Only group, a significant decrease in the Blood pressure was seen in–group treated with Vitamin D3 and Calcium. 36 subjects (65%) in the vitamin D3–calcium group compared with 27 (51%) subjects in the calcium group showed a decrease in SBP of 15 mm Hg or more (P =0.04). Conclusions: Vitamin D3 supplementation, by a dose that effectively increased vitamin D levels, systolic BP decreased significantly as compared to the diastolic Blood pressure. A larger randomized controlled study is required to further substantiate the results