EFFECTS OF CHRONIC HYPERTENSION CAUSED BY REPEATED EPISODES OF AIR JET STRESS ON THE PLASMA LEVELS OF TSH,T3 AND T4 IN WISTAR RATS

Nessaibia  Issam; Chouba  Ibtissem; Tahraoui Abdelkrim

Volume : III, Issue : XI, November - 2014

EFFECTS OF CHRONIC HYPERTENSION CAUSED BY REPEATED EPISODES OF AIR JET STRESS ON THE PLASMA LEVELS OF TSH,T3 AND T4 IN WISTAR RATS

Nessaibia Issam, Chouba Ibtissem, Tahraoui Abdelkrim

Abstract :

Disruptions of hypothalamic–pituitary–thyroid (HPT) axis in response to chronic crises of hypertension is relatively less known mainly regarding the defense mechanisms of the body facing a stressful external aggression and the repercussions caused by neuroendocrine mediation related to this axis. This study deals experimentally with a social deficit model on Wistar rats. This state of hypertension is caused by using chronic exposure to 1 bar 2 hours / day of air jet stress. The results show a significant increase in the TSH plasma and T3, T4 symptomatic of hyperthyroidism. This may be directly caused by the direct impact of hypertension on the activity of the para–ventricular hypothalamic nucleus (PVN) and the production of TRH, as well as a probable imbalance of immune rate Th1 / Th2 towards a Th2 hormonal profile triggered by the stress and consequently, the production of anti–TSH.