Effects of Cilnidipine on Heart rate and Uric Acid Metabolism in Patients of Essential Hypertension â€“ in Tertiary Care Hospital

Nidhi Singh; Ashok Kumar Sharma; Manoj Kumar; Prakash Kumar

Volume : V, Issue : X, October - 2016

Effects of Cilnidipine on Heart rate and Uric Acid Metabolism in Patients of Essential Hypertension â€“ in Tertiary Care Hospital

Nidhi Singh, Ashok Kumar Sharma, Manoj Kumar, Prakash Kumar

Abstract :

Background: The Relation Between Hypertension And Hyperuricemia Has Been Established By Epidemiological Studies. Calcium Channel Blockers Are One Of The First Line Drugs For Newly Diagnosed Patients Of Essential Hypertension. Cilnidipine Is A New Calcium Channel Blocker Act By Blocking Both L & N Type Of Calcium Channel. Method:the Aim Of This Study Is To Compare The Effectiveness Of Amlodipine And Cilnidipine In Patients Of Essential Hypertension And Their Effects On Heart Rate And Serum Uric Acid Levels. Out Of 100 Enrolled Patients 92 Completed The Study. They Are Randomly Assigned To Amlodipine (N= 47) And Cilnidipine (N= 45) Groups. Cilnidipine (Started At 10 Mg/Day, Then Adjusted To 5–20 Mg/Day) And Amlodipine (Started At 5 Mg/Day, Then Adjusted To 2.5–10 Mg/Day). Results:after 24Th Weeks Of Study Patients Of Cilnidipine Groups Showed Significant Reduction In Heart Rate And Serum Uric Acid Levels From Base Line (P Value = 0.00). Conclusion:in Clinical Setting Where Both Hypertension And Hyperuricemia Coexist Cilnidipine Can Be Promising Drug Of Choice.