Effects of Platinum Containing Anticancer  Drugs Cisplatin, Carboplatin Aand Oxaliplatin  on Behavioral Parameters in the Male Albino  Rat (Rattus Norvegicus)

M. S. Sastry; Snehal Dighade

Volume : II, Issue : V, May - 2013

Effects of Platinum Containing Anticancer Drugs Cisplatin, Carboplatin Aand Oxaliplatin on Behavioral Parameters in the Male Albino Rat (Rattus Norvegicus)

M. S. Sastry, Snehal Dighade

Abstract :

Antineoplastic chemotherapies are widely used in many therapeutic protocols and are responsible for numerous side effects. While studying the effects of platinum containing anticancer drugs such as Cisplatin, Carboplatin and Oxaliplatin on the reproductive system and thyroid gland of rats, some alterations in the behavioral parameters including locomotory, ocular, cutaneous, dental etc. were noticed with the low chronic doses (2.5mg/KgBW) and high chronic doses (15mg/KgBW). Such studies would be useful to ophthalmologist, dermatologist, and oncologist and in clinical management of oncology patients.