Volume : V, Issue : IV, April - 2016

Effects of Protoporphyrin on Renal Ischemia/Reperfusion Injury

Mai Barakat, Faten Zhran, Mohamed El Adl, Mahmoud Gabr

Abstract :

 The present study investigated the effects of CoPP (potent HO–1) inducer on renal dysfunctions in renal ischemia/ reperfusion injury. 27 male Sprague Dawley rats were randomized into 3 groups; sham group, ischemic group (left renal ischemia + right nephrectomy), CoPP group (left renal ischemia + right nephrectomy+ CoPP 20 mg/kg 30 min before renal ischemia). It was found that renal ischemia caused significant increase in serum creatinine, uric acid and urea and deteriorations of kidney morphology. Administration of CoPP caused significant improvement in all studied parameters and kidney morphology compared to ischemic group (p< 0.05). We concluded that CoPP has renoprotective effect against renal I/R injury.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Mai Barakat, Faten Zhran, Mohamed El Adl, Mahmoud Gabr Effects of Protoporphyrin on Renal Ischemia/Reperfusion Injury International Journal of Scientific Research, Vol : 5, Issue : 4 APRIL 2016

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