Volume : IV, Issue : IX, September - 2015

Effects of Sarcosine on the Stability of Cytochrome C

Bairagi C. Mallick

Abstract :

The effect of sarcosine on the stability of Cytochrome c (Cyt c) was investigated in the presence of GuHCl, GuSCN and sarcosine by chemical and heat–induced unfolding studies. The chemical unfolding data in the presence of GuHCl and GuSCN demonstrated that GuSCN destabilizes the protein more effectively than GuHCl. The thermodynamic parameters obtained clearly indicate that sarcosine stabilizes the protein by forcing the protein to acquire a native like structure. This study supports the earlier reports and clearly shows that sarcosine can effectively offset the destabilizing effects of GuHCl and GuSCN to protect the protein by acquiring a native like conformation.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Bairagi C. Mallick Effects of Sarcosine on the Stability of Cytochrome C International Journal of Scientific Research, Vol : 4, Issue : 9 September 2015

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