Volume : IX, Issue : I, January - 2020

Efficacy of Once a Month Single Dose Intravenous (Deferoxamine) versus Daily Oral (Deferasirox) Iron Chelator in Thalassemia Major: An Open Label Randomized Parallel Group Active Control Interventional Trial

Dr Ratna Bhojak, Dr Jayendra Gohil, Dr Mehul Gosai, Dr Bibin Varghese

Abstract :

Objective: Compare efficacy of Once a Month Single Dose Intravenous (Deferoxamine) with Daily Oral (Deferasirox) Iron Chelator in Thalassemia Major. Methodology: In this open label trials Patients were randomized by chit method after informed consent and allocated to two groups. Group A was administered Inj Deferoxamine by intravenous route once during monthly blood transfusions and Group B received Tab Deferasirox administered daily. The monitoring was done by serum Ferritin level every two months. Results: The primary outcome was decrease in ferritin level over 6 months from the baseline. Decrease in serum ferritin (%) over six months for Group A was 46±18 and Group B was 25±17 with significant difference between the two groups (p=0.001). The cost of treatment per kilo weight was not significantly different. Conclusion: We observed that Intravenous Deferoxamine once a month is a better and cheaper iron chelator as compared to the daily subcutaneous regimen;

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Article: Download PDF    DOI : 10.36106/ijsr  

Cite This Article:

EFFICACY OF ONCE A MONTH SINGLE DOSE INTRAVENOUS (DEFEROXAMINE) VERSUS DAILY ORAL (DEFERASIROX) IRON CHELATOR IN THALASSEMIA MAJOR: AN OPEN LABEL RANDOMIZED PARALLEL GROUP ACTIVE CONTROL INTERVENTIONAL TRIAL, Dr Ratna Bhojak, Dr Jayendra Gohil, Dr Mehul Gosai, Dr Bibin Varghese INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-9 | Issue-1 | January-2020

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