Efficacy of riboflavin in combating arsenic intoxication in testes of mice.

Dr.Sajal Kumar Dey; Dr.Sachi Nandan Kundu; Dr.Gobinda Chandra Sadhukhan

Volume : IV, Issue : VIII, August - 2015

Efficacy of riboflavin in combating arsenic intoxication in testes of mice.

Dr. Sajal Kumar Dey, Dr. Sachi Nandan Kundu, Dr. Gobinda Chandra Sadhukhan

Abstract :

Heavy metal toxicity is alarmingly increasing in present day earth. Arsenic is one such heavy metal that is prevalent in Indian subcontinent and is causing serious threat to mankind. Arsenic is a potent gonotoxic heavy metal that causes severe oxidative stress in male gonadal tissue. Total protein content, an indication of metabolic health of an organ, is found to decrease gradually over long term exposure to arsenic. Activities of stress enzymes like acid & alkaline phosphatase and lipid peroxidase are increased significantly in arsenic treated mice, indicating cytotoxic effects of arsenic on testis. Riboflavin is able to ameliorate all such cytotoxic effects towards normal and thus can become an alternative in combating arsenic intoxication in male gonads.