Volume : VIII, Issue : V, May - 2019

Efficacy of Sofosbuvir and Ribavirin in non cirrhotic chronic hepatitis C patients with Genotype 3

Dr Raese Noor Khan, Dr Aadil Bashir Rather, Dr Mohsin Rashid, Dr Gul Javaid

Abstract :

Introduction: HCV is a leading cause of chronic liver disease in both industrialized and developing countries. The high number of chronically infected individuals, the burden of disease and the absence of a vaccine indicates that treatment will form part of the control of the disease. Aims and objectives :The aim of this study is to assess the efficacy of sofosbuvir and ribavirin in non cirrhotic chronic hepatitis C patients with Genotype 3.Materials and Methods: This was a prospective study carried in the department of Gastroenterology Sheri Kashmir Institute of medical sciences soura between 2015 to 2016 involving chronic non cirrhotic hepatitis C patients of Genotype 3 with age more than 18yrs. Data analysis was performed using the IBM SPSS version 22.Results and observations:The total number of patients was(n=50). The mean age was (40.2 ±11.62) yrs with male patients being 20 (40%) and female patients 30 (60%). In treatment naïve group we had 40 while in treatment experienced group we had 10 patients. Sustained virological response at twelve weeks of the completion of treatment (SVR12) in treatment naïve was 100% while in the treatment experienced it was 80.0%. Sustained virological response (SVR12) difference among male and female patients was statistically not significant. Discussion: The results of our study were consistent with other studies although some differences were there due to difference in sample size . The final results were very encouraging regarding the efficacy of the drugs.Conclusion:The oral sofosbuvir and ribavirin results in high rates of sustained virological response in patients with chronic hepatitis C genotype 3 patients. This treatment offers an alternative to pegylated interferon based regimen, is cost effective , easy to adminster as the therepy is oral and also convenient.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

EFFICACY OF SOFOSBUVIR AND RIBAVIRIN IN NON CIRRHOTIC CHRONIC HEPATITIS C PATIENTS WITH GENOTYPE 3, Dr Raese Noor Khan, Dr Aadil Bashir Rather, Dr Mohsin Rashid, Dr Gul Javaid INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-5 | May-2019

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