Efficacy of Transdermal Fentanyl Patches In Acute Post Operative Pain Relief: A Randomised Double Blinded Placebo Controlled Trial

Dr Charly Chacko Joseph; Dr Dewan Roshan Singh; Dr Sivashanmugam; Dr Jaya V; Dr. Ravishankar M

Volume : IV, Issue : I, January - 2015

Efficacy of Transdermal Fentanyl Patches In Acute Post Operative Pain Relief: A Randomised Double Blinded Placebo Controlled Trial

Dr Charly Chacko Joseph, Dr Dewan Roshan Singh, Dr Sivashanmugam, Dr Jaya V, Dr. Ravishankar M

Abstract :

The aim of this study was to assess the efficacy and safety of 25microg/hr transdermal fentanyl patch in acute postoperative pain relief by analysing the degree of sp� of rescue analgesic consumption and side effect profile. 60 ASA I & II patients between 20-60 years, undergoing major orthopaedic and gynaecological procedures were included. Patch was applied 3 hrs before the surgery. All patients were anaesthetised as per standard protocol and in the postoperative ward rescue analgesia was delivered via PCA morphine. A blinded observer visited the patient at multiple intervals and recorded the quality of analgesia, rescue analgesic consumption and complications till 48 hours and the patch was removed at the end of 72 patch hours. Average reduction of rescue analgesic consumption was about 20 % reached maximum of 27% and attained statistical significance at the end of 48 post operative hours. It was concluded that the 25 μg/hr fentanyl patch applied 3 hrs before the surgery helps to relieve acute post operative pain as part of multimodal analgesic regimen.