Elevation of Free Prostate  Specific Antigen (fPSA) in Cancer Patients Adenosine Deaminase (ADA) Binds and Stimulates Plasminogen (pg) activation on 1LN Human Prostate Cancer cells.

M.A. Majid Adil; Shaikh Mahmood; Mohd. Abbas Hyder; Shahana Sarwar

Volume : VI, Issue : X, October - 2017

Elevation of Free Prostate Specific Antigen (fPSA) in Cancer Patients Adenosine Deaminase (ADA) Binds and Stimulates Plasminogen (pg) activation on 1LN Human Prostate Cancer cells.

M. A. Majid Adil, Shaikh Mahmood, Mohd. Abbas Hyder, Shahana Sarwar

Abstract :

The Prostate Specific Antigen (PSA) is the best and most commonly used tumor maker for prostate in clinical practice these days ^(1,2). It is a glycoprotein has molecular weight of 33KD. PSA is very routinely used in the diagnosis and follow up of prostate disease, specially prostate cancer ^(3,4). Prostate Specific Antigen (PSA) is formed in two different molecular types in serum; they are free PSA (fPSA) and complex PSA (cPSA), the serum of which form the total PSA (tPSA).fPSA is mostly used in the detection of Prostate cancer ⁽⁵⁾. Free PSA 28 kda is eliminated by glomerular filtration. The date revealed that the patients with end stage of renal dysfunction prolonged dialysis with increase percent of fPSA ^{(6,7, 8, 9)}.