ELEVATION OF SERUM AMINOTRANSFERASES (ALT, AST), ALKALINE PHOSPHATASE (ALP), LACTATE DEHYDROGENASE (LDH) AND CREATINE PHOSPHOKINASE (CPK NAC) IN DUCHENNE’S MUSCULAR DYSTROPHY (DMD) PATIENTS

Mohammed Siddique Ahmed Khan; Mohammed Ibrahim Shaik; Shaikh Mahmood

Volume : V, Issue : XI, November - 2016

ELEVATION OF SERUM AMINOTRANSFERASES (ALT, AST), ALKALINE PHOSPHATASE (ALP), LACTATE DEHYDROGENASE (LDH) AND CREATINE PHOSPHOKINASE (CPK NAC) IN DUCHENNE’S MUSCULAR DYSTROPHY (DMD) PATIENTS

Mohammed Siddique Ahmed Khan, Mohammed Ibrahim Shaik, Shaikh Mahmood

Abstract :

Duchenne�s Muscular Dystrophy (DMD) is a severe type of muscular dystrophy (1).The symptom of muscle weakness (2). Typically muscle loss occur first in the upper legs and pelvis followed by those of the arms. This can result in trouble in standing up (1). Most are unable to walk by the age of twelve (2). Affected muscles may look larger due to increase fat content. Scoliosis is also common. Some may have intellectually disability. Females with a single copy of the defective gene may show mild signs and symptoms. This disorder is X – linked recessive, two thirds of cases are inherited from a person�s parents while one third of cases are due to a new mutation (3). It is caused by a mutation in the gene for the protein dystrophin (3, 4). The present study enrolled 235 subjects including 55 DMD patients and 180 healthy controls. DMD was characterized by elevation of serum ALT, AST, ALP, LDH, and CK respectively. Aim The objective of this study to ascertain the serum levels of transaminoferases, alkaline phasphatase, lactate dehydrogenase in patients with DMD to correlate with muscle enzyme such as creatine kinase.