Elevation of Serum Gamma–Glutamyltransferase Enzyme and the Role  of Some Divalent Metals in Hepatitis Sera

Namama S. Hamad; Diary I.Tofiq; Avan A.Ahmad

Volume : II, Issue : VI, June - 2013

Elevation of Serum Gamma–Glutamyltransferase Enzyme and the Role of Some Divalent Metals in Hepatitis Sera

Namama S. Hamad, Diary I. Tofiq, Avan A. Ahmad

Abstract :

The effect of different divalent ions as potential and activator of serum gamma-glutamyltransferase GGT activities in human (male and female) with hepatitis was assessed using biochemical assays. Serum fluid was obtained from 50 cases (30 normal). Serum GGT activity were elevated in hepatitis (88.41� 9.31 IU/L)in comparison with control object (23�6.7) by about four fold. The study was carried out in optimum pH value 8.2 and 37 C0 by which the enzyme possess highest activity. Effects of potassium ,sodium, cupper, calcium ,and zinc on serum GGT activities were tested after addition of these metal (2mM)in the presence of the salts, they shows the inhibitory effect (63.41�2.43 IU/L),(69.56�4.75 IU/L),(69.90�8.31 IU/L),(64.26�3.81 IU/L)and (60.87�6.08) respectively, while magnesium and cobalt reflects a stimulatory effect on enzyme activity in hepatitis sera (164.32�0.81 IU/L) and (101.5�0.55IU/L).from these results it can be concluded that the metals studied may have a role in initiating and controlling cellular proliferation, through their effects on modulating the activities of the possible marker for GGT enzyme activity.