EPIDEMIOLOGICAL AND CLINICO-PATHOLOGICAL ANALYSIS AND OUTCOMES OF EXTRA-INTESTINAL GIST AT A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Sravanti Balaga; Vutukuru Venkatarami Reddy; Chandrakasan Chandramaliteeswaran; Musunuru Brahmeswara Rao; Lokesh Arora; Sudish Durgesh

Volume : IX, Issue : VIII, August - 2020

EPIDEMIOLOGICAL AND CLINICO-PATHOLOGICAL ANALYSIS AND OUTCOMES OF EXTRA-INTESTINAL GIST AT A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Sravanti Balaga, Vutukuru Venkatarami Reddy, Chandrakasan Chandramaliteeswaran, Musunuru Brahmeswara Rao, Lokesh Arora, Sudish Durgesh

Abstract :

INTRODUCTION: Extraintestinal GIST (EGIST) is a rare mesenchymal tumor. There is lack of sufficient literature regarding EGISTs. We have undertaken a retrospective observational study to analyze the epidemiology, clinicopathological features and outcomes of EGISTs. METHODS: All patients with the diagnosis of EGIST in the department of Surgical Gastroenterology, SVIMS from January 2015 to December 2019 were included. Patient�s demographics, laboratory and imaging findings, intra–operative findings, tumor pathology and outcomes were analyzed. RESULTS: Fourteen patients were included. Of these, 8 (57.14%) were males. Mean age was 53.43 years. Most patients (85.71%) presented with abdominal pain. Most common site of EGIST was retroperitoneum (50%). Preoperative imaging was diagnostic of GIST of gastro–intestinal origin in all patients. 71.43% tumors were >10cm in size and 50% had >10 mitotic index. Twelve patients underwent radical surgery. All were advised adjuvant therapy. Mean hospital stay was 7.07 days. Median survival was 38.5 months (range 4–60 months). CONCLUSION: EGISTs are more likely to be malignant, large in size, with high mitotic rates. Imaging may not be accurate for diagnosis. Owing to low incidence of EGISTs, multi–center studies are required to study their clinical and pathological behavior.