EPIDEMIOLOGICAL EVALUATION OF PARATHYROID HORMONE IN UROLITHIASIS

Neeraj Agarwal; Ashish Gupta; Vinay Tomar; S S Yadav; Shivam Priyadarshi

Volume : VII, Issue : VIII, August - 2018

EPIDEMIOLOGICAL EVALUATION OF PARATHYROID HORMONE IN UROLITHIASIS

Neeraj Agarwal, Ashish Gupta, Vinay Tomar, S S Yadav, Shivam Priyadarshi

Abstract :

Background: Hyperparathyroidism has been reported to account for as many as 5–8% of all calcium stone formers. Around 15–21 % patients will have renal calculi as their presenting complaints.Aim of this study is to identify the metabolic derangement in association with PTH hormone in patients of urolithiasis.

Methods: All patients with urolithiasis(renal and/or ureteric) were evaluated for parathyroid hormone. Patients were divided in two groups – group A (with normal PTH level = 4.7–114 pg/ml) and group B (with raised PTH = >114pg/ml). Patients with raised creatinine(>1.6), known case of hyperparathyroidism and those who refused for PTH evaluation were excluded from study.

Results: Total of 230 patients were available for analysis out of which 22 patients had raised PTH.PTH was significantly raised in recurrent (p=.02), staghorn calculi (p=.01) and with stone burden >2.5cm.

Conclusions: Ours is probably the 1^st study to evaluate ureteric calculi and stone burden in association to raised PTH. Young age, Bilateral, recurrent and larger stones are more prone to have raised PTH.