Volume : V, Issue : II, February - 2016

ESTIMATION OF URINARY PROTEIN: CREATININE INDEX IN NEWLY DIAGNOSED DIABETIC PATIENTS

Rimy Charak, Ashutosh Kumar, Ruhi Charak, Dr Sumit Dokwal

Abstract :

<p><p> Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long–term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels.1 Proteinuria has been recognized as one of the earliest signs of renal function deterioration in diabetes mellitus. In this study, an attempt has been made to establish the Protein: Creatinine Index (PCI) in random urine samples, as a convenient, quick and reliable method for the estimation of proteinuria in diagnosing and monitoring diabetic nephropathy in newly diagnosed diabetes mellitus patients. Total of 50 samples were collected from the IPD and OPD patients, 25 patients aged 25 to 65 years, who were diagnosed as diabetics and were confirmed by the estimation of fasting serum glucose (>126 mg/dl). 25 normal healthy subjects were age and sex matched with the diabetic patients, selected as the Controls. The comparison of urinary protein, urinary creatinine and urinary protein:creatinine index(PCI) between control and study group was analysed using unpaired “ t”–test. The urinary protein levels were significantly increased, urinary creatinine levels were decreased and urinary protein:creatinine index was significantly increased in newly diagnosed diabetics as compared to the non–diabetics(controls). This study suggests that random urine PCI can be a good predictor of significant proteinuria in diabetic nephropathy. This test could be a reasonable alternative to the 24–hour urine sample collection for the detection of significant proteinuria in diabetes mellitus patients.</p></p>

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Rimmy Charak, Ashutosh Kumar, Ruhi Charak, Dr Sumit Dokwal Estimation of Urinary Protein: Creatinine Index in Newly Diagnosed Diabetic Patients International Journal of Scientific Research, Vol : 5, Issue : 2 February 2016

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