EVALUATION OF 25– HYDROXY VITAMIN D LEVELS IN RHEUMATOID ARTHRITIS AND CORRELATION WITH DISEASE ACTIVITY

SHIKHAA MAHAJAN; SHUBHANGI SHARMA; SUVARNA PRASAD; GAGANDEEP SINGH

Volume : VIII, Issue : VI, June - 2019

EVALUATION OF 25– HYDROXY VITAMIN D LEVELS IN RHEUMATOID ARTHRITIS AND CORRELATION WITH DISEASE ACTIVITY

Shikhaa Mahajan, Shubhangi Sharma, Suvarna Prasad, Gagandeep Singh

Abstract :

Introduction:Vitamin D has anti–inflammatory, antiproliferative and immunomodulatory action and its deficiency is associated with many autoimmune disorders like RA, IDDM Aims & Objectives:Estimate serum 25 hydroxyl vitamin D in patients diagnosed with RA and find out correlation between serum vitamin D levels and disease severity in RA. Materials and Methods:Hospital based cross–sectional study conducted on 50 cases of RA and 50 controls. RA cases were diagnosed according to the 2010 ACR–EULAR classification criteria. Disease activity was measured in patients of RA according to DAS–28. Serum 25– Hydroxy vitamin D was assayed by direct competitive chemiluminescence immunoassay. Results:Average age was 45.96�12.39 years in cases. RA was almost two times more in females as compared to males. Significant positive correlation was seen between age and RA score in cases. Maximum numbers of cases were in moderate category of disease activity. Vitamin D levels were lower in RA cases as compared to controls and this difference was statistically very significant & Highly Significant Negative correlation was seen between Vitamin D and RA score in cases. Conclusion:RA is more in females and cases had significantly lower serum vitamin D levels and it may be one of the causes leading to the worsening of RA. As the inflammatory burden increases in RA, the levels of vitamin D are reduced