Evaluation of abnormal Serum Creatine Kinase and Lactate Dehydrogenase Activity in Patients with Hypothyroidism

Dr. Savita KC Rathore; Dr. Khushbu Suryaprakash Soni

Volume : VI, Issue : XII, December - 2017

Evaluation of abnormal Serum Creatine Kinase and Lactate Dehydrogenase Activity in Patients with Hypothyroidism

Dr. Savita Kc Rathore, Dr. Khushbu Suryaprakash Soni

Abstract :

Background: Hypothyroidism , one of the most common endocrine disorders. resulting from insufficient production or decreased action of thyroid hormone.30–80% of hypothyroid patients presents with muscular symptoms. Aims and Objectives: The aims of the present study were to determine the activities of serum Creatine kinase (CK) and lactate dehydrogenase (LDH) in hypothyroidism patients, and to evaluate the relationship between CK, LDH and TSH levels. Material and Methods: The present work was conducted in the Department of Clinical Biochemistry at Sri Aurobindo Institute of Medical Sciences, Indore. Serum CK and LDH were measured in 55 patients with known history of hypothyroidism and the results were compared with that of 30 healthy adults who taken as control group. Results: A positive correlation found between CK, LDH levels with TSH levels. The results showed the CK and LDH levels significantly (p<0.0001) higher in patients with hypothyroidism in comparison to control group. Conclusion: The significant increase in serum CK and LDH activities shows that muscle involvement occurs in hypothyroid patients and the role of CK as an alternative diagnostic tool in patients of thyroid disorder can be evaluated.