Volume : VII, Issue : IV, April - 2018

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF PUNICA GRANATUM

Dr. Muthukavitha. G, Dr. Vasanth. S

Abstract :

AIMS AND OBJECTIVE: To evaluate the antidepressant activity of punicagranatum in Swiss albino mice. MATERIALS AND METHODS: Thirty ined male albino mice weighing 20–25 grams were selected from central animal house. They were divided into five groups of six animals each. The control group I received normal saline 10 ml/kg intraperitoneally, standard group II received fluoxetine (20 mg / kg, intraperitoneally) and test groups III, IV, V receivedethanolic extract of punicagranatum in graded doses 100mg/kg, 200mg/kg and 400 mg /kg per orally . Antidepressant activity was assessed by using Forced swim test. The results were tabulated and analysed with suitable statistical method. RESULTS: Ethanaolic extract of Punicagranatum showed statistically significant antidepressant activity at all the three test doses (P< 0.05). The results were comparable to that produced by standard drug fluoxetine. CONCLUSION:Punicagranatumhas antidepressant activity which is comparable to fluoxetine. Further, studies are essential to prove the anti–depressant effect of Punicagranatum in human.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. MUTHUKAVITHA.G, Dr. VASANTH.S, EVALUATION OF ANTIDEPRESSANT ACTIVITY OF PUNICA GRANATUM, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-4 | April-2018

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