Evaluation of Herbal Mucoadhesive Gel Containing Coriandrum Sativum and Curcumin as a Local Drug Delivery Agent - A Novel In-Vitro Study

Fulbel SG; Rajhans NS; Moolya NN; Mhaske NH; Marvania PB; Chemte SZ; Awari AK

Volume : IX, Issue : V, May - 2020

Evaluation of Herbal Mucoadhesive Gel Containing Coriandrum Sativum and Curcumin as a Local Drug Delivery Agent - A Novel In-Vitro Study

Fulbel Sg, Rajhans Ns, Moolya Nn, Mhaske Nh, Marvania Pb, Chemte Sz, Awari Ak

Abstract :

Ayurveda is world�s ancient system of medicine that evolved in India A lot of herbal medicines are used for traditional healing. In comparison to synthetic medicines, they have low side effects, are effective and acceptable amongst patients. The current study evaluated the effects of combined herbal essenitial oil (Curcumin and Coriandrum sativum) in subjects with chronic periodontitis. Four bioadhesive polymers of mucoadhesive gels (curcumine 1g, coriandrum sativum 1g, carbopol 940, sodium carboxymethylcellulose) were prepared based on varying concentration of 0.5,1 and 1.5 and labelled as formulations (F) – F1, F2 and F3. In this invitro study, their physicochemical tests‚ mucoadhesive strength, drug release and antibacterial activity against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans were evaluated. Among the three gel formulations, F2 and F3 showed satisfactory mucoadhesion, homogeneity, viscosity, physical appearance, consistency and the formulations could flow easily through 21 G needle. However, F2 was better in terms of efficacy than F3 in terms of drug release. Based on in vitro release and mucoadhesion studies, F2 produced significant growth inhibition zones against Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. It was concluded that F2 was best formulation for further clinical evaluation of the formulation.