Volume : V, Issue : VI, June - 2016

EVALUATION OF HYPOGLYCEMIC EFFECT OF ALOE VERA IN GUINEAPIGS

Ndibualonji B. B. V. , Kabongo T. J. B.

Abstract :

 The objective of this study was to evaluate the hypoglycemic effect of the methanolic extract of Aloe vera plant’s leaves on cavia porcellus, used in Congolese traditional medicine for diabetes treatment. A hyperglycemia test caused orally was done on 24 guinea–pigs divided into 3 groups of 8 guinea–pigs each. The first group (group 1), received 2 g/kg of glucose solution, and 6 mg/kg of physiological saline solution (control); the second group (group 2) received the same amount of glucose, then 6 mg/kg of glibenclamide solution (oral antidiabetic); the last group (group 3) received the same amount of glucose, with 300 mg/kg of methanolic extract of Aloe vera plant’s leaves. For glycemia test, blood samples were taken 15 minutes before the overload in glucose (T –15), then a few seconds before this overload (T0), and finally 15 minutes (T15), 30 minutes (T30), 60 minutes (T60), 90 minutes (T90), 120 minutes (T120), 150 minutes (T150) and 180 minutes (T180) after the overload in glucose. In group 1, the glycemia increased by 73% at T15 to reach the peak at T60, i.e. an increase of 136% compared to baseline (T0). This increase in glycemia was significantly higher than that observed at the same time in groups 2 and 3. Then, between T 90 and T180, we observed in group 1 a progressive reduction of glycemia. But this reduction was significantly weaker than that observed in groups 2 and 3. When we compared the glycemia evolution in animals of groups 2 and 3, we observed the same increase at T15, respectively 47% and 53%. However, in group 3, glycemia continued to increase to reach the peak at T30, i.e. an increase of 92% compared to baseline, although in group 2, glycemia started to decrease at T30. We concluded that the methanolic extract of Aloe vera plant’s leaves has a hypoglycemic effect but this effect is weaker than that of glibenclamide

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

NDIBUALONJI B.B. V., KABONGO T. J. B. EVALUATION OF HYPOGLYCEMIC EFFECT OF ALOE VERA IN GUINEAPIGS International Journal of Scientific Research, Vol.5, Issue : 6 JUNE 2016

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