EVALUATION OF MEAN PLATELET VOLUME (MPV), AS AN ATHEROSCLEROTIC MARKER IN TYPE 2 DIABETES MELLITUS PATIENTS.

Dr.Priyadarshini Biswal; Dr.Pranati Pradhan; Dr.Dilleswari Pradhan; Shrestha Panda

Volume : VI, Issue : VII, July - 2017

EVALUATION OF MEAN PLATELET VOLUME (MPV), AS AN ATHEROSCLEROTIC MARKER IN TYPE 2 DIABETES MELLITUS PATIENTS.

Dr. Priyadarshini Biswal, Dr. Pranati Pradhan, Dr. Dilleswari Pradhan, Shrestha Panda

Abstract :

This was a prospective observational study of patients with type 2 Diabetes Mellitus attending Dept.of Endocrinology and tests done in the endocrinology dept and regional diagnostic center and department of Pathology of SCB Medical College Cuttack.

A total number of 100 cases of type 2 Diabetes Mellitus patients and 100 non diabetes subjects with detailed clinical history including age, sex, height, weight, BMI, Blood pressure, duration of diabetes, associated complications, personal history(smoking, alcoholism),and family history were taken.Risk factors in diabetes cases were identified by history taking, and from lipid profile ,hypertention, BMI and hematological tests. On all cases routine CBC(Hb,TPC,MPV),Bloodsugar(FBS,PPBS),Lipid Profile and HbA1c were evaluated. Hyperglycemia leads to platelet hyper reactivity and platelet plays a major role in the pathogenesis of atherosclerosis.So diabetes patients are more prone to develop vascular complications like atherosclerosis and coronary artery disease(CAD).In our study it was found that MPV has a significant association with raised FBS and PPBS and these were similar to the study by Kodiatte et al[1].KT Ulutal et al [2] suggested an association between MPV and HbA1c and said that platelets of diabetic patients become more aggregable and reactive due to increased MPV.