Evaluation of oxidative stress and its impact on the antioxidant activities in patients with colorectal Carcinoma

Dr. Sanjeev Kumar Singh; Dr. Akshay Kumar Nigam; Dinesh Maraiya; Dr. Neelima Singh; Dr. Nivedita Singh

Volume : IV, Issue : VII, July - 2015

Evaluation of oxidative stress and its impact on the antioxidant activities in patients with colorectal Carcinoma

Dr. Sanjeev Kumar Singh, Dr. Akshay Kumar Nigam, Dinesh Maraiya, Dr. Neelima Singh, Dr. Nivedita Singh

Abstract :

The present study mainly highlights the occurrence of lipid peroxidation and possible eakdown of antioxidants in colorectal carcinoma patients as compared to healthy control subjects. Enzymatic and non–enzymatic parameters play an important role in cell protection against harmful influence of oxidative stress. Our aim of the present study was to investigate the levels of final lipid peroxidation products like (MDA) malondialdehyde and activity of antioxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSH–Px) in colorectal carcinoma. The study consisted of 30 diagnosed gastrointestinal carcinoma patients and an equal number of age and sex matched healthy control subjects. The Activity of MDA, glutathione peroxidase and superoxide dismutase were determined by spectrophotometric method. From this study, we observed that the MDA were increased significantly & antioxidants were altered highly significantly. Therefore, for the diagnosis of human colorectal carcinoma or recurrence, the study of lipid peroxidation & antioxidant defense mechanism may be useful tool along with the biopsy, biochemical & Pathological investigations.