IJSR - International Journal of Scientific Research

Geetanjali Sharma; Kirti Jain

Volume : VII, Issue : IV, April - 2018

Evaluation of Plumbago zeylanica L. plant extract using Micronucleus Assay in Mouse Bone marrow cells

Geetanjali Sharma, Kirti Jain

Abstract :

Herbal plants have always been used as a common source of medicines. Plumbago zeylanica is the most common plant used in Indian traditional system of medicine. In the present investigation, the preventive effect of Plumbago zeylanica plant extract was evaluated against cisplatin–induced micronucleus formation in the mouse bone marrow cells. The single i.p.administration of Plumbago zeylanica extract at the dose of 200 and 400 mg/kg body weight, 24 h prior the administration of cisplatin (at the dose of 6 mg/kg) have significantly prevented the micronucleus formations in a dose dependent manner in bone marrow cells of mice as compared to cisplatin group. Our result indicate that plant extract seems to have preventive potential against cisplatin –induced micronucleus formation in swiss mouse bone marrow cells.