Evaluation of risk markers for CVD among subjects with type 2 diabetes and dyslipidemia

Viji Krishnan; Dinesh Roy D; Rakhimol Rajan

Volume : VI, Issue : VII, July - 2017

Evaluation of risk markers for CVD among subjects with type 2 diabetes and dyslipidemia

Viji Krishnan, Dinesh Roy D, Rakhimol Rajan

Abstract :

Cardiovascular disease (CVD) is a leading cause of mortality and is responsible for one third of all global death in India. Type 2 diabetes mellitus and dyslipidemia both are the major risk factors for cardiovascular disease (CVD). There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. There are many known markers available to predict CVDs but seeing severity and rising morbidities in all age groups upgraded biomarkers are to be needed for an earlier assessment of CAD patient. The goal of the study was to evaluate the biochemical and molecular risk markers for CVD among subjects with type 2 diabetes and dyslipidemia. Various demographic, clinical and lifestyle characteristics of the study subjects were analyzed. The study was performed in 70 study subjects and 35 healthy control subjects. These subjects were observed with raised levels of MDA and increased micronuclei frequency. This study indicates that many of these biomarkers, alone or in combination, can play important role in prediction of CVD risks and status of morbidity. < clear="all" style="page–eak–before:auto;mso–eak–type:section–eak" />

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