Evaluation of serum lipid profile in oral cancer, potentially malignant disorders and in patients with tobacco habit-a case control study.

 Methodology: This study consist of 4 groups ie OC, PMDs, patients with habit of tobacco & Control group. 10 ml of fasting venous blood from all the subjects. Serum from this collected blood sample is used for the evaluation using BS–380 chemist autoanalyser and the results are subjected to statistical analysis using SPSS 16 software. The test applied is one way ANOVA.

Result: Serum TC is substantially reduced in OC, PMDs (P<0.001), (P<0.05) respectively. There is no significant change of TC in patients with habit (P>0.05). Serum TG is substantially reduced in OC patients when compared with PMDs, habit and control & is statistically significant (P<0.001). There is no significant change of TG in patients with PMDs, habit and control (P>0.05). Serum HDL is substantially reduced in OC &PMDs which is statistically highly significant (P<0.001). Patients with habit also showed lowered levels of HDL when compared with control but not statistically significant (P>0.05). There is decreased HDL in habit patient also but not significantly. The mean serum levels of LDL in all the groups (P>0.001) found that there is no significant changes. VLDL is substantially reduced in oral cancer patients which is statistically significant (p<0.001).There is no significant change of VLDL in patients in PMDs and habit patients (P>0.05). Conclusion: There is inverse relation between serum lipid profile and occurrence of OC & PMDs with no direct and overall significant influence associated with tobacco habit.