Evaluation of the optimum dose of clonidine for haemodynamic stability in upper abdominal surgery : a comparative study of three different doses

Sushil K. Nayak; Sujata Ghosh; Ramkrishna Mandal; Mousumi Niyogi

Volume : IX, Issue : V, May - 2020

Evaluation of the optimum dose of clonidine for haemodynamic stability in upper abdominal surgery : a comparative study of three different doses

Sushil K. Nayak, Sujata Ghosh, Ramkrishna Mandal, Mousumi Niyogi

Abstract :

Background: Increases in arterial blood pressure and heart rate is often seen with laryngoscopy and intubation due to sympathetic stimulation. It causes myocardial insufficiency or cereovascular accidents in the vulnerable population. Aims: To evaluate and compare three different doses of clonidine (1�g/kg ,2mcg/kg ,3mcg/kg ) in order to find out the optimum dose of clonidine for better haemodynamic stability. Methodology: 150 patients scheduled for abdominal surgical procedures were divided randomly into three groups CL–1, CL –2 and CL–3 ( N= 50 in each arm) and received clonidine in the dose of 1 �g/kg ,2 �g/kg and 3 �g/kg respectively , The heart rate, systolic, diastolic and mean arterial pressures were recorded at basal , intraoperative and postoperative period. Results: There was no variation in HR , SBP , DBP and MBP in all groups at basal , 10 minutes after clonidine infusion, during induction , 1 hour and 2 hour after extubation . But they statistically varied significantly immediately after intubation and 3,5,10,40,70 minutes after intubation in intraoperative period and also immediately after extubation . Better control was attained in group CL–3 . Conclusion: 3mcg/kg IV dose of Clonidine given preoperatively effectively attenuates the pressor response to laryngoscopy and intubation. It also renders haemodynamic stability in the intraoperative and postoperative period