Exploration and Comparison of Hepatoprotective Activity of Aqueous Extract of Tinospora Cordifolia –An Experimental Study

Dr. Yogesh Kumar Goyal; Dr. Vipin Kumar

Volume : V, Issue : III, March - 2016

Exploration and Comparison of Hepatoprotective Activity of Aqueous Extract of Tinospora Cordifolia –An Experimental Study

Dr. Yogesh Kumar Goyal, Dr. Vipin Kumar

Abstract :

 Aim of the Study To explore the hepatoprotective activity of T. cordifolia. Materials and Methods Albino Wistar rats weighing 150–200g of either sex were divided into six groups of six animals each. Group I was given normal saline (PO), group II carbon tetrachloride(CCl4) (IP), group III Liv.52 syrup for twenty days followed by carbon tetrachloride, group IV, V & VI received aqueous extract of T. cordifolia (1ml/100g twice daily) orally for 10, 20 & 30 days respectively followed by CCl4 administration. Blood was collected from anaesthetized animals & Alanine transaminase (ALT), Alkaline phosphatase (ALP) & total bilirubin were estimated. Results ALT, ALP & Total bilirubin levels were significantly increased in CCl4 treated group while T. cordifolia displayed significant reduction in rise in these parameters in group IV to VI. Conclusion It can be concluded from the present study that T. cordifolia extracts is potent hepatoprotective agent.