EXPRESSION OF EPITHELIAL MESENCHYMAL TRANSITION MARKERS AT INVASIVE TUMOR FRONT IN PRIMARY HEAD AND NECK SQUAMOUS CELL CARCINOMA

Dr. SHANKAR M; Dr. AGARWAL K; Dr. KUMAR. S; Dr. SINGH S

Volume : VII, Issue : XI, November - 2018

EXPRESSION OF EPITHELIAL MESENCHYMAL TRANSITION MARKERS AT INVASIVE TUMOR FRONT IN PRIMARY HEAD AND NECK SQUAMOUS CELL CARCINOMA

Dr. Shankar M, Dr. Agarwal K, Dr. Kumar. S, Dr. Singh S

Abstract :

Background: The head and neck cancers is the sixth cancer by incidence worldwide.^[1]Few studies showed that reduced E–cadherin expression and positive vimentin expression is associated with decrease in differentiation and stage disease and hence poor prognosis of the patient. ^[2,3] METHODS: Sixty newly diagnosed HNSCC cases were included. H&E staining and immunohistochemistry for E–cadherin and Vimentin was performed. RESULTS: Most common site was oral cavity 71.6%. Out of 60 cases 67% cases showed reduced E–cadherin expression (p=0.013), 58% cases showed positive vimentin expression at ITF (p=0.245). Reduced E–cadherin and positive vimentin expression at ITF seen more in TNM stage I and II and also seen more in well differentiated tumor (p<0.001). CONCLUSION: Most common site involved was oral cavity and significant correlation was found between reduced E–cadherin expression, but no significant correlation was found with positive vimentin expression at ITF.