Extended Spectrum Beta � Lactamase (ESBL) Mediated  Resistance to Antibiotics Among Klebsiella Pneumoniae  in In Tertiary Care Hospital, Jamnagar, Gujarat

Dr. Hiral Gadhavi; Dr. Mala Sinha; Dr. Ullas Machhar; Dr. Kanizfatma Durani; Dr. Pratik Parmar; Dr. Gopi Makwana

Volume : II, Issue : I, January - 2013

Extended Spectrum Beta � Lactamase (ESBL) Mediated Resistance to Antibiotics Among Klebsiella Pneumoniae in In Tertiary Care Hospital, Jamnagar, Gujarat

Dr. Hiral Gadhavi, Dr. Mala Sinha, Dr. Ullas Machhar, Dr. Kanizfatma Durani, Dr. Pratik Parmar, Dr. Gopi Makwana

Abstract :

INTRODUCTION: Resistance bacteria are emerging worldwide as a threat to the favourable outcome of common infections in community and hospitals. Now a days ESBL producing strain in Klebsiella pneumoniae lead to resistance among the organism toward cephalosporin and other antibiotics. AIM: To determine the prevalence and antibiotic susceptibility patterns of Extended Spectrum Beta- Lactamase producing Klebsiella pneumoniae isolated from various clinical samples. MATERIAL & METHODS: Clinical isolates of Klebsiella pneumoniae were confirmed by culture, staining & biochemical reaction. The isolates were subjected to susceptibility testing using Kirby- Bauer method of determining antimicrobial susceptibility and ESBL production was phenotypically determined using double disc synergy test. RESULTS: ESBL production was determined among 115 isolates of Klebsiella pneumoniae, out of 91 (79.13%) were express ESBL. CONCLUSION: Regular monitoring of antibiogram of organism, and avoiding misuse and overuse of antibiotics may reverse the undesired effects of multidrug resistant and ESBL producing Klebsiella pneumoniae.