Volume : VI, Issue : X, October - 2017
Factor V Leiden and Prothrombin gene mutations in patients with arterial thrombotic diseases from Kashmiri population
Mahrukh H Zargar, Syed Shafia, Qurteeba Mahajan, Rehana Ahmad, Nabeela Khan
Abstract :
Aim: The role of FVL mutation and prothrombin gene mutation have been well established in venous thrombolism. The aim of this study was to investigate whether these mutations have a role in arterial thrombotic disease namely ischemic stroke and intracranial hemorrhagic in Kashmiri population.
Methodology: A case–control study was designed with 75 ischemic stroke patients, 75 intracranial hemorrhagic patients and 100 healthy controls. The mutations were analysed using ARMS– PCR and PCR–RFLP approach.
Result: The FVL GA genotype was found to be to be significantly associated with the increased risk of ischemic stroke (p=0.03) while no association was found with intracranial haemorrhage (p=0.07). The prothrombin 20210 G > A mutation was not found in any of the cases or controls.
Conclusion: The increased frequency of FVL mutation in ischemic stroke patients indicates a significant role of this mutation in the development of ischemic stroke in our population. We therefore suggest the routine screening of FVL mutation as a thrombophilic marker in Kashmiri patients with arterial thrombosis.
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DOI : 10.36106/ijsr
Cite This Article:
Mahrukh H Zargar, Syed Shafia, Qurteeba Mahajan, Rehana Ahmad, Nabeela Khan, Factor V Leiden and Prothrombin gene mutations in patients with arterial thrombotic diseases from Kashmiri population, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-10 | October-2017
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References :
Mahrukh H Zargar, Syed Shafia, Qurteeba Mahajan, Rehana Ahmad, Nabeela Khan, Factor V Leiden and Prothrombin gene mutations in patients with arterial thrombotic diseases from Kashmiri population, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-10 | October-2017
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