FETAL OUTCOME IN EPILEPTIC MOTHERS ON ANTI EPILEPTIC DRUG THERAPY

Volume : VII, Issue : IV, April - 2018

Dr. Moses. P. Moorthy, Dr. Ani Thampi, Dr. A. V. Srinivasan, Prof. K. Bhanu

AIM: To study the fetal outcome in Epileptic mothers on Anti Epileptic Drug therapy.

METHODS: This is a prospective study done in the epilepsy division on GMK medical college, Salem, Tamilnadu, India. From January 2016 to

December 2017

Inclusion Criteria: Antenatal mothers suffering from epilepsy, on Anti Epileptic Drug Therapy are included and monitored to study the fetal

outcome.

Exclusion Criteria: Antenatal mothers are taking drugs for other medical illness are excluded.

RESULTS: This study is done in 100 Antenatal mothers on Anti Epileptic Drug Therapy. Patients were studied into mono and poly therapy groups.

The fetal outcome was studied as miscarriage, preterm delivery, intra uterine death, intra uterine growth retardation (IUGR), congenital

malformation, Statistical analysis revealed statistically significant unfavorable fetal outcome in epileptic patients on poly therapy (

patients on sodium valproate showed poor fetal outcome, Phenytoin. Carbamazepine, phenobarbitone. Showed statistically significant unfavorable

pregnancy outcome with polytherapy(P<0.0001). This study revealed statistically significant incidence of intra uterine death (

delivery (