Formulation and Characterization of Silanised Magnetic Nanoparticles Conjugated with Folic Acid: A  Nanocarrier System for Anticancer Drug Delivery

Naheef; K; Sivanarayanan  TB

Volume : III, Issue : VIII, August - 2014

Formulation and Characterization of Silanised Magnetic Nanoparticles Conjugated with Folic Acid: A Nanocarrier System for Anticancer Drug Delivery

Naheef, K, Sivanarayanan Tb

Abstract :

Nanotechnology has emerged as one of the very promising fields of biomedical research in the past few decades. Drug delivery is one of the areas where this technology has made remarkable progress. The article presents the formulation and characterization of the Magnetic nanoparticle (MNP) mediated targeted anticancer drug delivery system. Modifying the MNP nanocarrier with organic silane 3-aminopropyl triethoxy silane makes it more effective as it turns more biocompatible and the surface amino groups provide way to further functionalization. Conjugation with folic acid (FA) increases specific targeted drug delivery towards folate receptor be� cancer cells to improve anticancer effectiveness by increasing the tissue�s local concentration of drugs.