Volume : IV, Issue : VI, June - 2015

FORMULATION AND EVALUATION OF OMEPRAZOLE GASTRORETENTIVE FLOATING TABLETS FOR THE TREATMENT OF PEPTIC ULCER.

Bhavna Patel

Abstract :

This investigation describes the preparation and in vitro evaluation of gastroretentive floating tablet of Omeprazole by direct compression technique using varying concentrations of different grades of polymers (HPMC K4 M and HPMC K15 M) with sodium bicarbonate and citric acid were evaluated for their gel forming and release controlling properties. Sodium bicarbonate and citric acid were incorporated as gas generating agents. Omeprazole having short biological half life (2–3.5 h), absorption in the initial part of the small intestine and 50% absolute bioavailability of drug favor development of sustained release floating formulation. The effects of soluble components (sodium bicarbonate and citric acid), gel forming agents and amount of Omeprazole on drug release profile and floating properties were investigated. Tablets were prepared by direct compression technique. The tablets were characterized by lag time, floating time, weight variation, swelling index, drug content and dissolution profile. The results indicated that a high amount of floating agent and combination of HPMC K4 M and HPMC K15 M polymer favored the sustained release of Omeprazole from gastroretentive tablet formulations. Drug release study was evaluated for 7 hours using USP XXII paddle–type dissolution apparatus using 0.1N HCl as dissolution medium drug release of 94% of F6 formulation.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Bhavna Patel Formulation and Evaluation of Omeprazole Gastroretentive Floating Tablets for the Treatment of Peptic Ulcer. International Journal of Scientific Research, Vol : 4, Issue : 6 June 2015

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