Formulation and Invitro Evaluation of Floating Matrix Tablets of Cefditoren pivoxil: Effect of Effervescent agent on properties

Naga Raju Kandukoori; M. Spruha Shanthi; J. Sushma; G. Madhu; Ch. Ramya; M. Swapna; B. Deepika

Volume : VI, Issue : VI, June - 2017

Formulation and Invitro Evaluation of Floating Matrix Tablets of Cefditoren pivoxil: Effect of Effervescent agent on properties

Naga Raju Kandukoori, M. Spruha Shanthi, J. Sushma, G. Madhu, Ch. Ramya, M. Swapna, B. Deepika

Abstract :

The main purpose of this study was to check the effect of concentration of effervescent agent on floating and dissolution properties of tablets. In this study floating matrix tablets of Cefditoren pivoxil were prepared by using three different polymers like HPMC K4M, Xanthan gum and Guar gum with drug : polymer ratio of 1 : 1. Each polymer was used with two different concentrations (15% w/w and 20% w/w) of effervescent agent. Total six formulations were developed and evaluated for their floating and drug release properties. In this study it was confirmed that the concentration of effervescent agent has greatly affected the buoyant behavior of tablets and drug release rate controlling power of the polymer.