Volume : VII, Issue : IX, September - 2018

FORMULATION OF LORNOXICAM FLOATING TABLETS EMPLOYING OLIBANUM GUM AND HPMC K 15 M

G Chinna Devi

Abstract :

The objective of the study is to formulate and evaluate floating tablets of lornoxicam employing olibanum gum,a natural gum resin in comparison to HPMC K15 M, a synthetic cellulose derivative. Floating tablets of Lornoxicam were prepared employing olibanum gum and HPMC K15 M as matrix formers, sodium bicarbonate as gas generating agent and bees wax and ethyl cellulose as floating enhancers and the tablets were evaluated for Invitro buoyancy and drug release characteristics.

The floating characteristics of the formulations which contained sodium bicarbonate (15%) alone were not satisfactory with both the two polymers and need to be improved.Increasing the strength of sodium bicarbonate from 15% to 20% has not much improved the floating characteristics. Addition of beeswax (15%) and ethyl cellulose (5%) has significantly enhanced the buoyancy of the tablets formulated with both the two polymers.Lornoxicam release from the floating tablets prepared was slow and spread over 12 h and depended on the polymer used and composition of the tablets.

Drug release was diffusion controlled and followed zero order kinetics. Non–Fickian diffusion was the drug release mechanism from all the tablets formulated.Lornoxicam release from the tablets containing beeswax and ethylcellulose along with the matrix forming polymers was slow and spread over more than 12 h.  The T₉₀ values were in the range 9 h to over 12 h with these tablets. These tablets exhibited a floating time of 33 h after a floating lag time in the range 2–9 min.Olibanum is found suitable as matrix former for floating tablets and is comparable to HPMC K15M, a widely used polymer for floating tablets and for controlled release.Since olibanum gum is of natural origin it is non–toxic biocompatible and cheaper.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

G CHINNA DEVI, FORMULATION OF LORNOXICAM FLOATING TABLETS EMPLOYING OLIBANUM GUM AND HPMC K 15 M, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-9 | September-2018

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