Volume : VII, Issue : X, October - 2018

Function of Chitosans in composition with antibiotics in Pseudomonas aeruginosa

Javad Chehri

Abstract :

Chitosan and its derivative water soluble Chitosan oligosaccharide are used in a variety of applications in pharmaceutical preparations. In this study, 2 wild (ATCC 15729 and PAO1) and 2 mutant strains (PT121 and PT149) of  P. aeruginosa are investigated for drug–drug interactions in vitro. 10 antimicrobial agents (antibiotics) are combined with different degree of deacetylatedChitosans and Chitosan oligosaccharide. All the chitosans show synergistic activity with sulfamethoxazole, a sulfonamide antimicrobial agent. It is    interesting to observe that the MIC value for the MexEF–OprN overexpressing mutant strain of P. aeruginosais 5 fold higher than the other strains under investigation suggesting a possible role of this efflux pump in Sulfamethoxazole efflux. The findings suggest on the use         of chitosans as enhancing agent in combination with antibiotics in pharmaceutical preparations.       

 

 

 

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Javad Chehri , Function of Chitosans in composition with antibiotics in Pseudomonas aeruginosa, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-7 | Issue-10 | October-2018

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