GAD65 AUTOANTIBODIES AS A NOVEL MARKER IN THE DIAGNOSIS OF LATENT AUTOIMMUNE DIABETES IN ADULTS (LADA)

Pachpute Preeti; Badade Z G; Pachpute S R

Volume : VI, Issue : IX, September - 2017

GAD65 AUTOANTIBODIES AS A NOVEL MARKER IN THE DIAGNOSIS OF LATENT AUTOIMMUNE DIABETES IN ADULTS (LADA)

Pachpute Preeti, Badade Z G, Pachpute S R

Abstract :

Latent autoimmune diabetes in adults (LADA) accounts for 2%–12% of all cases of diabetes. Patients are typically diagnosed in young adults and are often misdiagnosed as type II DM. The aim is to study the association of GAD–65 autoantibodies as a marker in the diagnosis of LADA and to compare the clinical parameters, & metabolic factors in diabetic Patients. We studied 300 diabetic patients. A multiple regression was run to predict role of GAD 65 antibodies in LADA diagnosis from Age, HbA1c, BMI, Cholesterol & C–peptide. These variables statistically significantly predicted GAD 65 antibodies, P < 0.5. The results of our study in a diabetic population revealed that the prevalence of LADA (17.3%). while some anthropologic characteristics can be useful for the preliminary screening of LADA patients in a diabetic population, GAD 65 autoantibodies determination can be considered as confirmatory diagnostic markers for LADA.